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PubMed Publications :

1) A combined effort of 11 laboratories in the WHO African region to improve quality of Buruli ulcer PCR diagnosis: The "BU-LABNET".

Marion E, Hycenth N, Vedithi SC, Robbe-Saule M, Donkeng V, Ganlonon LM, Dissou A, Ngazoa SK, Kabedi MJ, Mabika Mabika A, Phillips R, Frimpong M, Yeboah-Manu D, Walker VY, Akinwale O, Issaka M, Bretzel G, Asiedu K, Eyangoh S.
PLoS Negl Trop Dis. 2022 Nov 4;16(11):e0010908. doi: 10.1371/journal.pntd.0010908. eCollection 2022 Nov. PMID: 36331971 Free PMC article.
Buruli ulcer is one of the 20 neglected tropical diseases in the world. This necrotizing hypodermitis is a chronic debilitating disease caused by an environmental Mycobacterium ulcerans. At least 33 countries with tropical, subtropical and temperate climates have reported Buruli ulcer in African countries, South America and Western Pacific regions. Read More

2) Multi-centric evaluation of Biomeme Franklin Mobile qPCR for rapid detection of Mycobacterium ulcerans in clinical specimens.

Frimpong M, Frimpong VNB, Numfor H, Donkeng Donfack V, Amedior JS, Deegbe DE, Dadson B, Ablordey A, Eyangoh S, Phillips RO, Vedithi SC.
PLoS Negl Trop Dis. 2023 May 25;17(5):e0011373. doi: 10.1371/journal.pntd.0011373. eCollection 2023 May. PMID: 37228126 Free PMC article.
The gold standard for detection of Mycobacterium ulcerans is PCR due to its high accuracy in confirmation of suspected cases. But the available PCR assays are designed for standard size thermocyclers which are immobile and suited for reference laboratories often located long distances from endemic communities. Read More

3) Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease).

Yotsu RR, Richardson M, Ishii N.
Cochrane Database Syst Rev. 2018 Aug 23;8(8):CD012118. doi: 10.1002/14651858.CD012118.pub2. PMID: 30136733 Free PMC article.
BACKGROUND: Buruli ulcer is a necrotizing cutaneous infection caused by infection with Mycobacterium ulcerans bacteria that occurs mainly in tropical and subtropical regions. ...Studies evaluated various drugs usually in addition to surge … Read More

4) Targeting the Mycobacterium ulcerans cytochrome bc(1):aa(3) for the treatment of Buruli ulcer.

Scherr N, Bieri R, Thomas SS, Chauffour A, Kalia NP, Schneide P, Ruf MT, Lamelas A, Manimekalai MSS, Grüber G, Ishii N, Suzuki K, Tanner M, Moraski GC, Miller MJ, Witschel M, Jarlier V, Pluschke G, Pethe K.
Nat Commun. 2018 Dec 18;9(1):5370. doi: 10.1038/s41467-018-07804-8. PMID: 30560872 Free PMC article.
Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. ...As a result, Q203 is bactericidal at low dose against M. ulcerans replicati … Read More

5) Shortening Buruli Ulcer Treatment with Combination Therapy Targeting the Respiratory Chain and Exploiting Mycobacterium ulcerans Gene Decay.

Converse PJ, Almeida DV, Tyagi S, Xu J, Nuermberger EL.
Antimicrob Agents Chemother. 2019 Jun 24;63(7):e00426-19. doi: 10.1128/AAC.00426-19. Print 2019 Jul. PMID: 31036687 Free PMC article.
Buruli ulcer is treatable with antibiotics. An 8-week course of rifampin (RIF) and either streptomycin (STR) or clarithromycin (CLR) cures over 90% of patients. ...We conclude that it may be possible to cure patients with Buruli ulcer in 14 days or les … Read More

6) Buruli Ulcer, a Prototype for Ecosystem-Related Infection, Caused by Mycobacterium ulcerans.

Zingue D, Bouam A, Tian RBD, Drancourt M.
Clin Microbiol Rev. 2017 Dec 13;31(1):e00045-17. doi: 10.1128/CMR.00045-17. Print 2018 Jan. PMID: 29237707 Free PMC article. Review.
Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent, Mycobacterium ulcerans, derives from Mycobacterium marinum by genomic … Read More

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